Op-Ed Contributor: Our Failed Approach to Schizophrenia



TOO many pendulums have swung in the wrong directions in the United States. I am not referring only to the bizarre all-or-nothing rhetoric around gun control, but to the swing in mental health care over the past 50 years: too little institutionalizing of teenagers and young adults (particularly men, generally more prone to violence) who have had a recent onset of schizophrenia; too little education about the public health impact of untreated mental illness; too few psychiatrists to talk about and treat severe mental disorders — even though the medications available in the past 15 to 20 years can be remarkably effective.


Instead we have too much concern about privacy, labeling and stereotyping, about the civil liberties of people who have horrifically distorted thinking. In our concern for the rights of people with mental illness, we have come to neglect the rights of ordinary Americans to be safe from the fear of being shot — at home and at schools, in movie theaters, houses of worship and shopping malls.


“Psychosis” — a loss of touch with reality — is an umbrella term, not unlike “fever.” As with fevers, there are many causes, from drugs and alcohol to head injuries and dementias. The most common source of severe psychosis in young adults is schizophrenia, a badly named disorder that, in the original Greek, means “split mind.” In fact, schizophrenia has nothing to do with multiple personality, a disorder that is usually caused by major repeated traumas in childhood. Schizophrenia is a physiological disorder caused by changes in the prefrontal cortex, an area of the brain that is essential for language, abstract thinking and appropriate social behavior. This highly evolved brain area is weakened by stress, as often occurs in adolescence.


Psychiatrists and neurobiologists have observed biochemical changes and alterations in brain connections in patients with schizophrenia. For example, miscommunications between the prefrontal cortex and the language area in the temporal cortex may result in auditory hallucinations, as well as disorganized thoughts. When the voices become commands, all bets are off. The commands might insist, for example, that a person jump out of a window, even if he has no intention of dying, or grab a set of guns and kill people, without any sense that he is wreaking havoc. Additional symptoms include other distorted thinking, like the notion that something — even a spaceship, or a comic book character — is controlling one’s thoughts and actions.


Schizophrenia generally rears its head between the ages of 15 and 24, with a slightly later age for females. Early signs may include being a quirky loner — often mistaken for Asperger’s syndrome — but acute signs and symptoms do not appear until adolescence or young adulthood.


People with schizophrenia are unaware of how strange their thinking is and do not seek out treatment. At Virginia Tech, where Seung-Hui Cho killed 32 people in a rampage shooting in 2007, professors knew something was terribly wrong, but he was not hospitalized for long enough to get well. The parents and community-college classmates of Jared L. Loughner, who killed 6 people and shot and injured 13 others (including a member of Congress) in 2011, did not know where to turn. We may never know with certainty what demons tormented Adam Lanza, who slaughtered 26 people at an elementary school in Newtown, Conn., on Dec. 14, though his acts strongly suggest undiagnosed schizophrenia.


I write this despite the so-called Goldwater Rule, an ethical standard the American Psychiatric Association adopted in the 1970s that directs psychiatrists not to comment on someone’s mental state if they have not examined him and gotten permission to discuss his case. It has had a chilling effect. After mass murders, our airwaves are filled with unfounded speculations about video games, our culture of hedonism and our loss of religious faith, while psychiatrists, the ones who know the most about severe mental illness, are largely marginalized.


Severely ill people like Mr. Lanza fall through the cracks, in part because school counselors are more familiar with anxiety and depression than with psychosis. Hospitalizations for acute onset of schizophrenia have been shortened to the point of absurdity. Insurance companies and families try to get patients out of hospitals as quickly as possible because of the prohibitively high cost of care.


As documented by writers like the law professor Elyn R. Saks, author of the memoir “The Center Cannot Hold: My Journey Through Madness,” medication and treatment work. The vast majority of people with schizophrenia, treated or untreated, are not violent, though they are more likely than others to commit violent crimes. When treated with medication after a rampage, many perpetrators who have shown signs of schizophrenia — including John Lennon’s killer and Ronald Reagan’s would-be assassin — have recognized the heinousness of their actions and expressed deep remorse.


It takes a village to stop a rampage. We need reasonable controls on semiautomatic weapons; criminal penalties for those who sell weapons to people with clear signs of psychosis; greater insurance coverage and capacity at private and public hospitals for lengthier care for patients with schizophrenia; intense public education about how to deal with schizophrenia; greater willingness to seek involuntary commitment of those who pose a threat to themselves or others; and greater incentives for psychiatrists (and other mental health professionals) to treat the disorder, rather than less dangerous conditions.


Too many people with acute schizophrenia have gone untreated. There have been too many Glocks, too many kids and adults cut down in their prime. Enough already.


Paul Steinberg is a psychiatrist in private practice.



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How will going off the 'fiscal cliff' affect the U.S.?









You've heard the predictions for what happens if the country goes over the "fiscal cliff": The economy will shrink, nervous consumers will stop spending, and the stock market will plunge.


But those doomsday predictions are overblown, some professional investors say.


Even if Congress and the White House can't reach a deal, the higher taxes and lower government spending that would follow would kick in only gradually. A recession is not guaranteed.








What's much more important to the stock market, the experts say, are economic fundamentals.


"History has shown that the economy is going to do what the economy is going to do," said Scott Carmack, co-portfolio manager at Leader Capital in Portland, Ore. "And politics don't create some sort of disaster."


Regardless of what happens, the "fiscal cliff" — sweeping tax increases and government spending cuts set to take effect Jan. 1 — is going to dominate the headlines and the market for the next week.


What's going to happen in the stock market between now and the budget deadline of Dec. 31?


The market hates uncertainty. If there's no deal, expect stocks to fall.


"We always knew we were going to get some volatility here," Carmack said. "Depending on leaders in Washington to come to some kind of agreement is like pulling teeth."


Besides, there are other incentives for people to pull money out of the market. Some professional investors are selling to lock in gains for the year. Others are selling because investments could be taxed at higher rates next year.


"It's been a pretty good year in the market," said Peter Tuz, co-manager of the Chase Growth and Chase Mid Cap Growth mutual funds in Charlottesville, Va. The Standard & Poor's 500 index is up more than 13% in 2012.


"People might look at that uncertainty and say, 'I'm happy with that, and now I'll take some money aside, and sell,'" he said.


What about after Jan. 1?


Deal or no deal, many investors don't expect the effects of the fiscal impasse to linger in the stock market for too long.


One big reason is that everyone has seen it coming for months.


"We're not overly concerned," said David Hefty, chief executive of Hefty Wealth Partners in Auburn, Ind. "The thing to keep in mind is that what hurts investors, what hurts the market, are things that are unexpected."


He added: "Everybody has 2008 burned into their minds. They think the 'fiscal cliff' will be the next 2008 event. A 2008 event is when nobody sees it coming, and everyone is blindsided. Nobody's going to be blindsided by this."


Hefty said he'd watch whether the Federal Reserve continues its policy of pumping money into the economy, and fundamentals such as housing and unemployment, to decide how to invest in 2013.


"We're looking at two key things that matter the most," he said. "The 'fiscal cliff' isn't one of them."


Donald Quigley, co-manager of the Artio Total Return Bond mutual fund, is more wary of the political effects than the economic effects. If Republicans and Democrats can't reach a compromise, he said, the world could take that as a sign that the United States government is dysfunctional.





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Jack Klugman dies at 90; star of TV's 'The Odd Couple,' 'Quincy'








Jack Klugman, the three-time Emmy Award-winning actor best known for his portrayals of slovenly sportswriter Oscar Madison on TV's “The Odd Couple” and the title role of the murder-solving medical examiner on “Quincy, M.E.,” died Monday at his home in Woodland Hills. He was 90.

Klugman had been in declining health for the last year, his son Adam said.

He had withdrawn from a production of “Twelve Angry Men” at the George Street Playhouse in New Brunswick, N.J., in Marchfor undisclosed health reasons. He had undergone successful surgery for cancer of the larynx in 1989.


PHOTOS: 2012 notable deaths


Klugman was the last surviving member of the cast that played the jury in “12 Angry Men,” the classic 1957 movie drama about deliberations in a first-degree murder trial. He was also a veteran of live TV dramatic anthology series in the 1950s and appeared in several episodes of “Twilight Zone.”

On Broadway, Klugman played Ethel Merman's boyfriend, Herbie, in the hit musical “Gypsy,” which earned him a 1960 Tony Award nomination. He won his first Emmy in 1964 for a guest appearance on “The Defenders.”

In 1965, he was back on Broadway, replacing Walter Matthau as Oscar Madison in the original production of “The Odd Couple,” Neil Simon's classic comedy about two friends with polar-opposite personalities who become roommates — one is divorced and the other just broke up with his wife.

PHOTOS: Jack Klugman -- 1922 - 2012


But that's not why Klugman landed the role of the casually sloppy Oscar Madison in the TV version of “The Odd Couple” opposite Tony Randall's fussy neat-freak Felix Unger.

Randall, who had appeared in a production of “The Odd Couple” with Mickey Rooney, had wanted Rooney to play Oscar in the TV series. But executive producer Garry Marshall fought for Klugman.

In his 2005 book “Tony and Me: A Story of Friendship,” Klugman wrote that during the first rehearsals for the TV series, Marshall told him he'd never seen him play Oscar on Broadway.

“What!” said Klugman. “Then why did you fight for me?”

“I saw you in ‘Gypsy,’ “ said Marshall. “You did a scene with Ethel Merman and I was impressed because as she was singing to you, she was spitting a lot and it was getting on your clothes and your face and in your eyes. You never even flinched. I said to myself, ‘Now that's a good actor.’ “

Although “The Odd Couple” was not a hit when it aired on ABC from 1970 to 1975, it has had a long life in syndication and forever cemented the reputation of its two stars as one of TV's great comedy teams.

In TV Guide's 1999 listing of “TV's Fifty Greatest Characters Ever,” Felix and Oscar ranked No. 12.

“Many acting tandems have played Neil Simon's testosterone-and-teacup duo over the years on stage and screen,” the magazine observed. “But Tony Randall and Jack Klugman are the Felix and Oscar we love most. For five unflaggingly creative seasons, they were the most evenly matched ‘Odd Couple' imaginable.”

Although Randall claimed he was “very little like” Felix, Klugman said in a 1996 interview with The Times, that he was “pretty close” to Oscar.

In fact, when members of the wardrobe department initially sought to outfit the unkempt Oscar, they looked no further than Klugman himself.

“They paid me $360 for everything in my closet, and I still made a profit on the deal,” he told Sports Illustrated in 2005.

As Oscar, Klugman won Emmys in 1971 and 1973 for outstanding continued performance by an actor in a leading role in a comedy series.

After “The Odd Couple” ended its run in 1975, Klugman said the last thing on his mind was doing another TV series.

Having “spent five years in the best situation comedy ever devised” and having worked with Randall, “the nicest guy in this business,” Klugman said, he turned down one pilot series script after another, particularly those for sitcoms.

But when he received the script for “Quincy, M.E.,” he said, he saw “potential in it — the gimmick of a doctor who solves crime for the police by medical and scientific deduction. It was not just another cop show.”

And with “Quincy, M.E.” which ran on NBC from 1976 to 1983 and earned Klugman four Emmy nominations, he saw a way to raise issues such as incest, child abuse, drunk driving and elderly abuse.

“I'm a muckraker,” he told the Chicago Tribune in 1993. “I saw the possibilities in ‘Quincy': We could entertain with what was essentially a good murder mystery but also do important shows on important subjects. This was why I got into the business.”

One of six children, Klugman was born in Philadelphia on April 27, 1922. His father, a financially struggling house painter, died when Klugman was 12. A year later, after a stint selling newspapers, Klugman began taking horse bets to earn extra money.

“The dealer said, ‘These guys will give you slips of paper. Just put them in the tin,'“ he recalled in a 1971 interview with The Times. “Then I was taking bets on the phone.”

A lifelong track aficionado, Klugman later owned a horse farm in Temecula, and his racehorse, Jaklin Klugman, finished third in the 1980 Kentucky Derby.

Back home in 1945 after serving in the Army during World War II, Klugman lost the $3,000 he had saved in U.S. savings bonds by betting on baseball games. Worse, he owed $500 to a loan shark and faced serious bodily injury unless he made a payment within three days.

Unable to come up with the cash, Klugman skipped town and moved to Pittsburgh, where he was accepted into the drama department of what is now Carnegie Mellon University. A few years later he moved to New York, where he landed parts in off-Broadway and summer stock.

He appeared in films such as “Days of Wine and Roses” and “Goodbye, Columbus,” and also starred in two short-lived situation comedies: “Harris Against the World” and “You Again?”

In 1989, Klugman, a heavy smoker, underwent surgery for cancer of the larynx in which the center of his right vocal cord was removed. Afterward, the actor famous for his raspy growl initially was unable to speak above a whisper.

After going public with his story a year-and-a-half later, he worked with voice specialist Gary Catona who put Klugman on a regimen of daily vocal exercises to strengthen his left vocal cord so that it could stretch to touch what was left of his right vocal cord and produce a sound.

His old friend Randall also played a key role in his return to acting in 1991.

After beginning his vocal exercises, Randall called Klugman to suggest that they do a one-night benefit performance of “The Odd Couple” on Broadway for Randall's new National Actors Theatre.

“I said to Tony, ‘I can't even talk. I don't know how I can do it,' “ Klugman recalled in a 1993 interview with the Chicago Tribune.

But, as he wrote in his memoir, after six months of working on his voice “like Rocky worked on his body,” the whisper “became a sound, and in time, the sound became a little voice. But was it enough to perform on Broadway?”

Nervous about facing an audience and hating the way he sounded, Klugman, who wore a small microphone on stage, was encouraged after getting his first laugh.

At the end of the performance, he took his bow to a standing ovation.

“After that, I knew I was back,” he said.

Klugman married actress and comedienne Brett Somers in 1953. They had been separated for many years when she died in 2007.

In addition to son Adam, he is survived by his wife, Peggy; son David; and two grandchildren.

Funeral arrangements are pending.

McClellan is a former staff writer.

news.obits@latimes.com






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Reaction to the death of actor Jack Klugman


Celebrities on Monday reacted to the death of "Odd Couple" star Jack Klugman, who died Monday at age 90. Here are samples of sentiments expressed on Twitter:


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"R.I.P. Jack Klugman, Oscar, Quincy a man whose career spanned almost 50 years. I first saw him on the Twilight Zone. Cool guy wonderful actor." — Whoopi Goldberg.


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"You made my whole family laugh together." — Actor Jon Favreau, of "Swingers," ''Iron Man" and other films.


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"I worked with Jack Klugman several years ago. He was a wonderful man and supremely talented actor. He will be missed" — Actor Max Greenfield, of the "New Girl" on Fox.


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"So sorry to hear that Jack Klugman passed away. I learned a lot, watching him on television" — Dan Schneider, creator of Nickelodeon TV shows "iCarly," ''Drake and Josh" ''Good Burger," ''Drake & Josh."


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Gifts That Keep Giving (if Not Exploding)


Gregory Tobias/Chemical Heritage Foundation Collections


A Chemcraft set from the mid-1950s. More Photos »







Ask scientists of a certain age about their childhood memories, and odds are they’ll start yarning about the stink bombs and gunpowder they concocted with their chemistry sets. Dangerous? Yes, but fun.




“Admittedly, I have blown some things up in my time,” said William L. Whittaker, 64, a robotics professor at Carnegie Mellon University who unearthed his first chemistry set, an A. C. Gilbert, in a junkyard around age 8. By 16, he was dabbling in advanced explosives. “There’s no question that I burned some skin off my face,” he recalled.


Under today’s Christmas tree, girls and boys will unwrap science toys of a very different ilk: slime-making kits and perfume labs, vials of a fluff-making polymer called Insta-Snow, “no-chem” chemistry sets (chemical free!), plus a dazzling array of modern telescopes, microscopes and D.I.Y. volcanoes. Nothing in these gifts will set the curtains on fire.


“Basically, you have to be able to eat everything in the science kit,” said Jim Becker, president of SmartLab Toys, who recalled learning the names of chemicals from his childhood chemistry set, which contained substances that have long since been banned from toys.


Some scientists lament the passing of the trial-and-error days that inspired so many careers. “Science kits are a lot less open-ended these days,” said Kimberly Gerson, a science blogger who lives outside Toronto. “Everything is packaged. It’s either ‘yes’ or ‘no.’ If you don’t get the right result, you’ve done it wrong and you’re out of chemicals.”


Others, though, say the new crop of science toys — even with their cartoonish packaging and heavy emphasis on neon goo — actually represent progress. More entertaining, educational and accessible than earlier products, which relied heavily on a child’s inner motivation, these toys may actually help democratize the learning of science and introduce children to scientific methods and concepts at an earlier age.


“I grew up in the 1960s, and a lot of the chemistry sets were kind of boring,” said William Gurstelle, a science and technology writer. “You’d go through the book, and at the end of the experiment you’d get some light precipitate at the bottom of the beaker. Maybe at most it changes color or something.”


Mr. Gurstelle’s books, which include “Whoosh Boom Splat” and “Backyard Ballistics,” teach people how to make dangerous projectiles, like a potato cannon that uses hair spray as launching fluid. But he had high praise for commercial science kits, which show children (among other things) how to make slime.



Jeff Swensen for The New York Times

William L. Whittaker at the Planetary Robotics Lab at Carnegie Mellon University surrounded by the robots he has created.



“Well, that’s a pretty cool thing to have when you’re done,” Mr. Gurstelle said. “You’re not going to really learn to be a chemist from a chemistry set when you’re in seventh grade; you’re just going to be inspired. The point is that new chemistry sets and new toys are just better, because the manufacturers have figured out how to make them more fun.”


Some toy makers, like SmartLab, Mr. Becker’s company, have used this philosophy to give classic toys a makeover. One of SmartLab’s takes on a chemistry set, for instance, is the Extreme Secret Formula Lab, which comes with “squishy-lidded bubble test tubes” and “an abundance of glow-in-the-dark powder.” The game of Mousetrap has been re-envisioned as the Weird and Wacky Contraption Lab, meant to bring out children’s Rube Goldberg talents. And the slot car tracks that Mr. Becker recalls snapping together in his youth have been translated into a robot called ReCon 6.0, which children can program to roam around.



Mike Kane for The New York Times

Jim Becker of SmartLab Toys.



“What we do is give kids the opportunity to learn through problem solving,” Mr. Becker said.


Of course, technology has also remade the experience of learning science. Children may be more likely to click on a science app than to go play outside.


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FDA warns medical practices about Botox from Canadian supplier









Federal regulators have warned more than 350 medical practices that Botox they may have received from a Canadian supplier is unapproved and could be counterfeit or unsafe.


The Food and Drug Administration said in a letter to the medical practices — nearly 20 of which are in the Los Angeles area — that batches of the wrinkle treatment shipped by suppliers owned by pharmacy Canada Drugs have not been approved by the FDA and that the agency cannot assure their effectiveness or their safety.


The FDA said Canada Drugs was previously tied to shipping unapproved and counterfeit cancer drugs.











The agency warned doctors about buying drugs from sources other than licensed U.S. pharmacies. It's the fifth warning the agency has made this year about foreign suppliers providing unapproved drugs.


In February, the agency warned 19 medical practices that they had received a counterfeit version of the cancer drug Avastin. On three more occasions the FDA issued similar warnings about counterfeit Avastin and Altuzan, another brand name for the same drug. The alerts were also primarily targeted at drugs distributed by Canada Drugs.


A request for comment from the drug distributor was not immediately returned.


Drug shortages have increased the financial incentives for some pharmacies to provide counterfeit or illegally imported drugs. The drugs subject to warnings have all been injectable treatments typically distributed through medical practices and not directly to patients.


In October, the FDA ordered operators of about 4,100 websites to immediately stop selling unapproved medications to U.S. consumers. The vast majority of those sites were operated by Canada Drugs.


Genuine Botox is made by Allergan Inc. in Irvine. Avastin is made by Swiss drug giant Roche Holding's Genentech unit in South San Francisco.


A link to the list of medical practices who were sent the letter can be found on the FDA website at http://1.usa.gov/R7jKiR.





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Raging fire guts Kabul market









KABUL, Afghanistan -- Firefighters battled through the night to contain a raging fire that swept through a market in the Afghan capital.

No injuries were reported, but the blaze destroyed hundreds of stores and millions of dollars worth of merchandise, Afghan police and firefighters said at the scene. 


Dealers at the neighboring currency exchange, the city’s largest, said they evacuated cash, computer equipment and records from their shops as the flames approached during the night. But in the morning, the market was jammed with people haggling over thick stacks of notes as smoke billowed overhead.





Col. Mohammed Qasem, general director of the Kabul fire department, said he suspected an electrical short was to blame for the fire. 


Gas canisters used to heat the stores propelled the flames, along with the cloth and clothing sold by many of the vendors, Qasem said. “It made it very big in a short time.”


Firefighters from the Afghan defense department and NATO forces were sent to assist. But the city’s notorious traffic and the market’s narrow lanes made it difficult for responders to maneuver their vehicles, Qasem said.


Abdulrahman, who like many Afghans has only one name, squatted near a fire truck with his head in his hands  as responders aimed a hose at the blackened ruins of a building still smoldering at noon Sunday, more than 12 hours after the fire broke out.


He said the building had contained three shops that he owned and a warehouse full of glassware, crockery and kitchen utensils. 


“I lost everything,” he said.


Shirali Khan complained that police hadn't allowed him to remove the goods from his four clothing stores.


“They thought we were all robbers,” he said.  “There’s only ashes left.”


ALSO:


Pope pardons former butler convicted of theft


Bombing kills local official, 7 other people in Pakistan


Tensions high as vote on proposed Egyptian constitution continues


Special correspondent Hashmat Baktash contributed to this report.






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'Hobbit' extends No. 1 journey with $36.7 million


LOS ANGELES (AP) — Tiny hobbit Bilbo Baggins is running circles around some of the biggest names in Hollywood.


Peter Jackson's "The Hobbit: An Unexpected Journey" took in $36.7 million to remain No. 1 at the box office for the second-straight weekend, easily beating a rush of top-name holiday newcomers.


Part one of Jackson's prelude to his "The Lord of the Rings" trilogy, the Warner Bros. release raised its domestic total to $149.9 million after 10 days. The film added $91 million overseas to bring its international total to $284 million and its worldwide haul to $434 million.


"The Hobbit" took a steep 57 percent drop from its domestic $84.6 million opening weekend, but business was soft in general as many people skipped movies in favor of last-minute Christmas preparations.


"The real winner this weekend might be holiday shopping," said Paul Dergarabedian, an analyst for box-office tracker Hollywood.com.


Tom Cruise's action thriller "Jack Reacher" debuted in second-place with a modest $15.6 million debut, according to studio estimates Sunday. Based on the Lee Child best-seller "One Shot," the Paramount Pictures release stars Cruise as a lone-wolf ex-military investigator tracking a sniper conspiracy.


Opening at No. 3 with $12 million was Judd Apatow's marital comedy "This Is 40," a Universal Pictures film featuring Paul Rudd and Leslie Mann reprising their roles from the director's 2007 hit "Knocked Up."


Paramount's road-trip romp "The Guilt Trip," featuring "Knocked Up" star Seth Rogen and Barbra Streisand, debuted weakly at No. 6 with $5.4 million over the weekend and $7.4 million since it opened Wednesday. Playing in narrower release, Paramount's acrobatic fantasy "Cirque du Soleil: Worlds Away" debuted at No. 11 with $2.1 million.


A 3-D version of Disney's 2001 animated blockbuster "Monsters, Inc." also had a modest start at No. 7 with $5 million over the weekend and $6.5 million since opening Wednesday.


Domestic business was off for the first time in nearly two months. Overall revenues totaled $112 million, down 12.6 percent from the same weekend last year, when Cruise's "Mission: Impossible — Ghost Protocol" debuted with $29.6 million, according to Hollywood.com.


Cruise's "Jack Reacher" opened at barely half the level as "Ghost Protocol," but with a $60 million budget, the new flick cost about $100 million less to make.


Starting on Christmas, Hollywood expects a big week of movie-going with schools out through New Year's Day and many adults taking time off. So Paramount and other studios are counting on strong business for films that started slowly this weekend.


"'Jack Reacher' will end up in a very good place. The movie will be profitable for Paramount," said Don Harris, the studio's head of distribution. "The first time I saw the movie I saw dollar signs. It certainly wasn't intended to be compared to a 'Mission: Impossible,' though."


Likewise, Warner Bros. is looking for steady crowds for "The Hobbit" over the next week, despite the debut of two huge newcomers — the musical "Les Miserables" and the action movie "Django Unchained" — on Christmas Day.


"We haven't reached the key holiday play time yet," said Dan Fellman, head of distribution for Warner. "It explodes on Tuesday and goes right through the end of the year."


In limited release, Kathryn Bigelow's Osama bin Laden manhunt saga "Zero Dark Thirty" played to packed houses with $410,000 in just five theaters, averaging a huge $82,000 a cinema.


That compares to a $4,654 average in 3,352 theaters for "Jack Reacher" and a $4,130 average in 2,913 cinemas for "This Is 40." ''The Guilt Trip" averaged $2,217 in 2,431 locations, and "Monsters, Inc." averaged $1,925 in 2,618 cinemas. Playing just one matinee and one evening show a day at 840 theaters, "Cirque du Soleil" averaged $2,542.


Since opening Wednesday, "Zero Dark Thirty" has taken in $639,000. Distributor Sony plans to expand the acclaimed film to nationwide release Jan. 11, amid film honors and nominations leading up to the Feb. 24 Academy Awards.


Opening in 15 theaters from Lionsgate banner Summit Entertainment, Naomi Watts and Ewan McGregor's tsunami-survival drama "The Impossible" took in $138,750 for an average of $9,250.


A fourth new release from Paramount, "The Sopranos" creator David Chase's 1960s rock 'n' roll tale "Not Fade Away," debuted with $19,000 in three theaters, averaging $6,333.


Universal's "Les Miserables" got a head-start on its domestic release with a $4.2 million debut in Japan.


Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Hollywood.com. Where available, latest international numbers are also included. Final domestic figures will be released Monday.


1. "The Hobbit: An Unexpected Journey," $36.7 million ($91 million international).


2. "Jack Reacher," $15.6 million ($2.5 million international).


3. "This Is 40," $12 million.


4. "Rise of the Guardians," $5.9 million ($13.7 million international).


5. "Lincoln," $5.6 million.


6. "The Guilt Trip," $5.4 million.


7. "Monsters, Inc." in 3-D, $5 million.


8. "Skyfall," $4.7 million ($9 million international),


9. "Life of Pi," $3.8 million ($23.2 million international).


10. "The Twilight Saga: Breaking Dawn — Part 2," $2.6 million ($6.6 million international).


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Estimated weekend ticket sales at international theaters (excluding the U.S. and Canada) for films distributed overseas by Hollywood studios, according to Rentrak:


1. "The Hobbit: An Unexpected Journey," $91 million.


2. "Life of Pi," $23.2 million.


3. "Rise of the Guardians," $13.7 million.


4. "Skyfall," $9 million.


5. "Wreck-It Ralph," $7.3 million.


6. "The Twilight Saga: Breaking Dawn — Part 2," $6.6 million.


7. "Pitch Perfect," $6 million.


8. "Les Miserables," $4.2 million.


9. "Love 911," $3.2 million.


10. "De L'autre Cote du Periph," $3.1 million.


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Online:


http://www.hollywood.com


http://www.rentrak.com


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Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.


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N.Y.U. and Others Offer Shorter Courses Through Medical School





Training to become a doctor takes so long that just the time invested has become, to many, emblematic of the gravity and prestige of the profession.




But now one of the nation’s premier medical schools, New York University, and a few others around the United States are challenging that equation by offering a small percentage of students the chance to finish early, in three years instead of the traditional four.


Administrators at N.Y.U. say they can make the change without compromising quality, by eliminating redundancies in their science curriculum, getting students into clinical training more quickly and adding some extra class time in the summer.


Not only, they say, will those doctors be able to hang out their shingles to practice earlier, but they will save a quarter of the cost of medical school — $49,560 a year in tuition and fees at N.Y.U., and even more when room, board, books, supplies and other expenses are added in.


“We’re confident that our three-year students are going to get the same depth and core knowledge, that we’re not going to turn it into a trade school,” said Dr. Steven Abramson, vice dean for education, faculty and academic affairs at N.Y.U. School of Medicine.


At this point, the effort involves a small number of students at three medical schools: about 16 incoming students at N.Y.U., or about 10 percent of next year’s entering class; 9 at Texas Tech Health Science Center School of Medicine; and even fewer, for now, at Mercer University School of Medicine’s campus in Savannah, Ga. A similar trial at Louisiana State University has been delayed because of budget constraints.


But Dr. Steven Berk, the dean at Texas Tech, said that 10 or 15 other schools across the country had expressed interest in what his university was doing, and the deans of all three schools say that if the approach works, they will extend the option to larger numbers of students.


“You’re going to see this kind of three-year pathway become very prominent across the country,” Dr. Abramson predicted.


The deans say that getting students out the door more quickly will accomplish several goals. By speeding up production of physicians, they say, it could eventually dampen a looming doctor shortage, although the number of doctors would not increase unless the schools enrolled more students in the future.


The three-year program would also curtail student debt, which now averages $150,000 by graduation, and by doing so, persuade more students to go into shortage areas like pediatrics and internal medicine, rather than more lucrative specialties like dermatology.


The idea was supported by Dr. Ezekiel J. Emanuel, a former health adviser to President Obama, and a colleague, Victor R. Fuchs. In an editorial in the Journal of the American Medical Association in March, they said there was “substantial waste” in the nation’s medical education. “Years of training have been added without evidence that they enhance clinical skills or the quality of care,” they wrote. They suggested that the 14 years of college, medical school, residency and fellowship that it now takes to train a subspecialty physician could be reduced by 30 percent, to 10 years.


That opinion, however, is not universally held. Other experts say that a three-year medical program would deprive students of the time they need to delve deeply into their subjects, to consolidate their learning and to reach the level of maturity they need to begin practicing, while adding even more pressure to a stressful academic environment.


“The downside is that you are really tired,” said Dr. Dan Hunt, co-secretary of the Liaison Committee on Medical Education, the accrediting agency for medical schools in the United States and Canada. But because accreditation standards do not dictate the fine points of curriculum, the committee has approved N.Y.U.’s proposal, which exceeds by five weeks its requirement that schools provide at least 130 weeks of medical education.


The medical school is going ahead with its three-year program despite the damage from Hurricane Sandy, which forced NYU Langone Medical Center to evacuate more than 300 patients at the height of the storm and temporarily shut down three of its four main teaching hospitals.


Dr. Abramson of N.Y.U. said that postgraduate training, which typically includes three years in a hospital residency, and often fellowships after that, made it unnecessary to try to cram everything into the medical school years. Students in the three-year program will have to take eight weeks of class before entering medical school, and stay in the top half of their class academically. Those who do not meet the standards will revert to the four-year program.


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TV firm All3Media to consolidate studios in Westchester









Britain's largest independent television production company, All3Media, will consolidate its Southern California studios in Westchester.


The company behind such shows as "Undercover Boss" and "Ramsay's Kitchen Nightmares" has agreed to rent two floors in a Howard Hughes Center office building near the 405 Freeway and Sepulveda Boulevard, real estate broker Jacob Bobek of Cushman & Wakefield said.


The lease for 51,000 square feet of space is valued at $16 million, Bobek said. All3Media's five Los Angeles-area studios are now in separate locations in Culver City and on the Westside, and the consolidation will reduce their total rented space about 20%.





More than half of All3Media's revenue comes from international operations, and the U.S. is its fastest-growing market, according to British industry website Broadcast. This month All3Media announced plans to pool its U.S. resources in a production hub headed by Eli Holzman.


The company will move about 220 workers to its new space at 6060 Center Drive in July, said broker Greg Lovett of Cushman & Wakefield, who also worked on the All3Media lease with landlord Equity Office Properties.


The floors All3Media will rent were previously occupied by video game maker Vivendi, Lovett said, which left behind about $750,000 worth of improvements turning the offices into creative-style space with exposed heating ducts and enhanced electric power supplies.


Nasty Gal adding L.A. office space


Fast-growing e-commerce company Nasty Gal will quintuple the size of its headquarters in a historic downtown Los Angeles office complex.


Nasty Gal, which sells women's clothes and accessories online, has agreed to expand its offices to 50,300 square feet in the PacMutual Building complex near Pershing Square. It will occupy the third and fourth floors of the "Carriage House," a Beaux Arts-style building that housed a garage, ballroom and dining facility when it was finished in 1926.


The landlord, Rising Realty Partners, bought the PacMutual complex in April. The three connected buildings were built for Pacific Mutual Life Insurance Co. as its headquarters starting at the turn of the 20th century. Previous owners endeavored to rent offices there to traditional white-collar companies, but Rising Realty has set out to also attract creative firms by emphasizing the historic nature of the property.


Nasty Gal's space will have 18-foot ceilings, exposed brick walls, marble floors and a vintage private elevator that was closed off by previous owners. Nasty Gal, which was founded six years ago, will also occupy part of the "Clock Building." That building is where Pacific Mutual once kept a large clock and a sign reading "Time to insure."


Rising Realty is refurbishing PacMutual and will add a "green wall" vertical landscape feature that will scale the Olive Street side of the six-floor Clock Building, said Christopher Rising, president of Rising Realty.


Terms of the seven-year agreement were not disclosed, but real estate data provider CoStar Group said the landlord is asking for about $2.73 a square foot per month.


"This new space will be a prolific extension of the Nasty Gal brand," said Carle Pierose of Industry Partners, the building's leasing agent.


Health plan to move headquarters to Rancho Cucamonga


Inland Empire Health Plan, a not-for-profit public health plan serving residents of Riverside and San Bernardino counties, will move its headquarters from San Bernardino to Rancho Cucamonga.


The company has agreed to rent 207,000 square feet in the Atrium at Empire Lakes, where it will consolidate its operations from five buildings into one, real estate broker Josh Gorin of Studley Inc. said. The 15-year lease with landlord Torchlight Investors is valued at about $84 million.


The health plan is a joint powers entity serving 565,000 residents through government-sponsored programs including Medi-Cal. It is expected to serve 900,000 members by 2014 as federal healthcare reforms take effect and the company enters the newly established California Health Exchange.


IEHP will begin moving most of its 1,000 employees to the Atrium at 10801 6th St. in the second quarter of next year.


The health plan lease is a large one for the Inland Empire, which has been plagued with empty office space since the economic downturn. Vacancy in the area near L.A./Ontario International Airport is about 30%, Gorin said.


"They are leasing a tremendous amount of space in a highly depressed market," he said.


roger.vincent@latimes.com





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